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Paying special consideration to earlier substance abuse and forensic background is definitely an integral part of psychiatric evaluation. Many of the clinical trials finding out the efficacy of ketamine in managing major depressive problem excluded individuals with histories of material abuse, and claimed that ketamine did not trigger dependence with multiple infusions soon after a brief duration of observations [15]. Can the opportunity of dependancy be totally dominated out if ketamine is prescribed repeatedly in excess of a protracted period?

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